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KMID : 0357419960260020259
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Korean journal of Virology
1996 Volume.26 No. 2 p.259 ~ p.268
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The Detection of ICD p24 Antigen Predicts Bas Prognosis in HIV-1 Infected Patients
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Abstract
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In order to evaluate the effect of viral load on the prognosis of human immunodeficiency virus 1 (HIV-1)-infected individuals, immune complex dissociated (ICD) serum p24 antigen (p24) by acid treatment was retrospectively measured for 50
HIV-infected
patient for 60 months. Among them. 27 patients were p24 positive (p24+) above 25pg/ml for 40.4±12 months and 23 patients were negative (p24-). Follow-up periods from HIV diagnosis were 63.0±19 months (range; 40-112) for the p24+ and 68.4±19
months
(range; 38-106) for the p24-, respectively (p>0.05). Mean CD4+ T cell counts in the p24+group decreased from 473±277/ul (median;373)to 157±150/ul (median; 111)for 60±16 months (5.3months P280/ul (median; 476) to 432±285/ul (median;382) for
63±19
months (2.5/month, P<0.01). From CD4+ T cell count>200/ul, the patients who progressed to AIDS of<200/ul were 13 of 23 (56%) in the p24+ and 4 of 22(18%) in p24-, respectively ((p<0.01). And the number of death in two groups were 6 (22%) and 1
(4%),
respectively ((p<0.01). Presumed survival in two group were about 12 and 24.5 years. These data suggest that viral load itselt be very important for the prognosis of HIV-in-fected patients.
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KEYWORD
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